顾勇－急性肾衰.ppt

文档介绍：Acute Renal Failure
2005-3-10
Huashan Hospital,Fudan University
1
Definitions
Rapid decline in GFR
2
Classification
Prerenal ARF
Intrinsic renal ARF
Postrenal ARF
3
Prerenal ARF
Intravascular volume deletion
Decreased cardiac output
Systemic vasodilatation
Renal vasoconstriction
Pharmacologic agents
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Intrinsic ARF
Diseases involving large renal vessels
Diseases involving renal microvasculature
Diseases of glomeruli
Diseases characterized by injury to renal tubules
Diseases of the tubulointerstitium
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Postrenal ARF
Ureteric obstruction
Bladder neck obstruction
Urethral obstruction
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Acute Tubule Necrosis
Etiology
Pathology
Pathophysiology
Clinical features
Differentiation
Management
7
Etiology
Ischemia
Exogenous toxins
Endogenous toxins
8
Pathology
Focal loss of tubular epithelium cells
Exposure of basement membrane
Loss of proximal tubular brush border
Necrosis in the outer medulla
9
Pathophysiology
Hemodynamic abnormalities
Tubule obstruction
Back-leakage
10