文档介绍：Cervical tumor
Cervical intraepithelial neoplasia(CIN)
Introduction
A group of precancerous lesion closely associated with
the cervical cancer,which reflect the continuous process
of the development of the cervical cancer.
caused by virus infection rarely develop cervical cancer
caused by multifactors may develop cervical cancer.
diagnosing system by NCI
(1).atypical squamous cells,ABC.
(2).low-grade squamous intraepithelial lesion,LSIL.
(3).high-grade squamous intraepithelial lesion ,HSIL.
LSIL means CIN I,rarely develop cervical cancer.
HSIL menas CIN II and III,may develop cervical cancer.
Etiology
HPV(human papillomaviruses) infection
Epidemiologic risk factors for CIN:
1,multiple sexual partners
2,high-risk sexual partner
3,early onset of sexual activity(<16)
4,a history of STDs(especially, HPV infection)
5,cigarette smoking
6,immunodeficiency
7,long-tem oral contraceptive pill use
Cervical Histological Specialty
(i).primal squamo-columnar junction
(ii).physiologic squamo-columnar junction
(iii).transformation zone
(iv).squamous metaplasia
(v).squamous epithelization
Pathology
Cervical intraepithelial neoplasia(CIN)
degree I: ie,mild dysplasia,
heterotype cells occupy lower 1/3 layer
degree II: ie,moderate dysplasia,
heterotype cells occupy the lower 2/3 layer
degree III: ie,severe dysplasia and carcinoma in situ,
heterotype cells occupy whole layer
Clinical findings
Usually no symptoms or signs
Early detection is extremely important
Diagnosis
Repeated cervical ctyology--TCT
Colposcopic examination
Biopsy—the most reliable method to make diagnosis