文档介绍：Rheumatoid Disease in Children 小儿风湿性疾病
Children’s Hospital of
Fudan University
Xu Hong
******@shmu.
Rheumatoid Disease Connective tissue diseases (包含有120种与关节、骨骼、肌肉等相关的疾病)
过敏性紫癜(anaphylactoid purpura)
类风湿性关节炎(JRA)
SLE(systemic lupus erythematosis)
皮肌炎(dermatomyositis)
硬皮病(scleroderma)
风湿热(rheumatic fever)
川崎病(Kawasaki disease)
Rheumatoid Disease in Children
The mon diseases:
Juvenile Rheumatiod Arthritis
Henoch-Schonlein purpura
Kawasaki Disease
(Mucocutaneous Lymph Node Syndrome, MCLS)
Rheumatic Fever
冠状动脉造影 Coronary angiogram
Henoch-Schonlein purpura
Alternative names:
Anaphylactoid purpura
Vascular purpura
Definition
Henoch-Schonlein purpura is a disease that has the symptoms
purple spots on the skin
joint pain
gastrointestinal symptoms
glomerulonephritis
(a type of kidney disorder)
History story
Schonlein's Purpura
( In 1837, Johan Schonlein )
the skin and joints are affected
but the gastrointestinal tract is not
Henoch's Purpura
(Later, his student, Eduard Henoch )
purpura spots on the skin and acute abdominal problems
not affected by joint disease
General conditions
a type of hypersensitivity vasculitis and inflammatory response within the blood vessel
It is caused by an abnormal response of the immune system
The exact cause for this disorder is unknown.
The syndrome is usually seen in children, but people of any age may be affected
It is mon in boys than in girls
Many people with Henoch-Schonlein purpura had an upper respiratory illness in the previous weeks
Causes and pathogenesis
An inflammatory disease of the small blood vessels (capillaries)
usually a self-limited disease
It is the mon form of childhood vascular inflammation (vasculitis) and results in inflammatory changes in small blood vessels