文档介绍：支气管哮喘 (Asthma )
哈尔滨医科大学临床第一医院
呼吸内科张一梅
A chronic inflammatory disorder of the airways
Characterized by
1、episodic airway narrowing
2、 increased reactivity
3、 pharmacologic and
spontanoud reversibility
The classic triad of symptoms:
1、Episodic expiratory dyspnea
2、persistent wheeze
3、Chronic cough
Other associated symptoms:
1、chest pain or tightness
2、sputum production
不可逆性狭窄
气道重塑
全球哮喘防治创议(GINA)
Global Initiative for Asthma
流行病学(Epidemiology)
Incidence:1-13%
1—4% in China
5—10% in USA
病因和发病机制 (Aetiology and Pathogenesis)
NOT VERY CLEAR
ic factors :
Environmental factors:
哮喘发病机制示意图
环境因素
遗传易感个体
炎症细胞、细胞因子
及炎症介质相互作用
神经调节失衡、上皮细胞
及气道平滑肌结构功能异常
气道炎症
气道高反应性
症状性哮喘
环境激发因子
Precipitating factors
Virus
Atmos
drugs
Others
House dust mite
parainfluenza
Cigarette smoking
B-blockers
Cold air
Flour,pollen
VirusRes
ozone
aspirin
emotion
Snimal danders
Syncytial rhinovirus
Sulphur dioxide
Fumes
grain
particulates
exercise
mycetes
Occupation