文档介绍：现代肿瘤医学 2014年8月第22卷第8期 MODERNONCOLOGY,,V(),NQ-o8 ·1841· 甘露聚糖肽联合顺铂胸腔内灌注治疗恶性胸腔积液的临床观察陈绍锋,黄杰,肖纬宇 Clinicalobservationofintra——pleuralinjectionofmannatideandlow——dosecisplatinin thetreatmentofmalignantpleuraleffusion ChenShao~ng,HuangJie,XiaoWeiyu DepartmentofMedwalOncology,TheSecondAffiliatedHospitalofGuangdongMedwalCollege,GuangdongZh。ang524003,China. 【Abstract】Objective:avityperfusionwithman— natidepluscisplatin(DDP):Totalof60patientswithmalignant ,31casesintreatmentgroupweretreatedwithmannatide (80—100mg)plusDDP(60mg)byintra—pleura1injection;29casesincontrolgrouponlyreceivedDDP60rag,The treatmentforbothgroupswasrepeatedtwiceperweekandcontinuedfor1—:Theresponserateofthe %(26/31),%(17/29)— callysignificantdifferencebetweenthetwogroups(P<).Lifequalityimprovementrateofthetreatmentgroup %,%ofthecontrolgroup(P<).Themainside—effectoftwogroupsweremildgas— trointestinalreaction,eukopenia,:Intra—pleuralinjectionofmannatideplusDDPto treatofmalignantpleuraleffusioncanproducesynergeticaction,tobemoreeffectiveandbenefittoimprovethepa— tient~lifequality,andadversereac