文档介绍：MolecularBiologyoftheCellTopicsCancerStemCellsBiomembranesNanobiologyGradingClassAttendance&Discussion(20%)TeamPresentation(40%)FinalExam(40%)Presentations5-memberteam(self-assembled)Selectonepaper(Science,Nature,Cell)withinthefieldsofcancer,stemcellorapoptosis,discussextensivelybytheteam,andpreparefora20-minutepresentation(10-15slides)Addressthefollowinginyourpresentation:Scientificquestionthepaperwastryingtoanswer;Experimentalapproachestakenandmaintechniquesused;Majorfindingsandconclusions;Significanceofthepaper;&CancerCancer:TheBottomLineInanimals,cellnumbersareunderexquisitecontrolLossofthiscontrolleadstoproliferationofunwantedcellsCancerariseswhentheabovesituationreachesacertaindegreeCancervsTumorCancercellsaremalignanttumor()cellsAllcancercellsareeventuallycapableofmetastasisTissueCultureSystemsPrimaryCellCulturesSecondaryCellStrainsContinuousCellLinesTransformedCellsReducedcelladhesionRound-upmorphologyReducedserumrequirementsElevatedhexoseuptakeAnchorage-independentgrowth(abilitytogrowinsemi-solidmedia,softagarLossofdensity-dependentgrowthinhibition(“ContactInhibition”)SecretionofplasminogenactivatorCapableofformingtumorinapproprietesettingCausesofCancer icmutationsInheritedcancersusceptibilitiesCarcinogenicsubstancesVirusesRadiation