文档介绍：腹水多打顺铂 [循环热灌注大剂量顺铂诊疗胃肠道肿瘤腹水的疗效分析]
[摘要] 目标 比较循环热灌注大剂量顺铂和单纯灌注化疗诊疗胃肠道肿瘤腹水的近期疗效及并发症。 方法 同期胃肠道肿瘤腹水患者103例，随机分为两组，观察组经过腹腔内穿刺置双管建立循环双通路，先缓慢放出腹腔积液，再行循环热灌注，并于灌注液中加入大剂量顺铂，诊疗结束后腹腔内存留1 000～1 500 mL灌注液；对照组置腹腔引流管，先予腹腔放液，后灌注1 000 mL加有大剂量顺铂的液体，24 h后放出液体。两个疗程后对其疗效及副反应进行比较。 结果 两组103例患者两个疗程后全部可评价疗效，观察组有效率为%，显著高于对照组的%，两组间差异有高度统计学意义。 结论 循环热灌注大剂量顺铂诊疗胃肠道肿瘤腹水安全、微创，不良反应少而轻，近期疗效显著。
[关键词] 循环热灌注；大剂量顺铂；胃肠道肿瘤；腹水
[中图分类号] R735 [文件标识码] A [文章编号] 1673-721007-0056-02
Curative effect analysis of circulates the hot irrigation large dose along the platinum treatment gastro-intestinal tract tumor ascites
CAO Ruyao1 LU Dapeng2 LI Wandai1
of Tumor, the People"s Hospital of Suning County, Hebei Province, Suning 062350, China; Center, Beijing Shijitan Hospital, Beijing 100038, China
[Abstract] Objective To compare the efficacy and complications of high-dose cisplatin loop perfusion with simple infusion chemotherapy for the treatment of gastrointestinal tumor ascites. Methods 103 cases of gastrointestinal tumor patients with ascites were divided into two group. Observed group was given high-dose hot cisplatin and the temperature was 43℃. Control group was given high-dose cisplatin without hot temperature, after 24 hours to release liquid. Results Two groups of 103 patients after two courses of all efficacy evaluation, efficient of observation group was %, significantly higher than the control g