文档介绍：Chapter 6 Regulation of gene expression 第六章基因表达调控
From genes to characters 从基因至性状的过程
Regulation of gene expression in prokaryotes原核生物基因表达的调节
Regulation of gene expression in eukaryotes真核生物基因表达的调节
Genes Characters
基因性状
Characters性状
Genes基因
Environment环境
DNA mRNA Protein蛋白质
From genes to characters 从基因至性状的过程
The conception: one gene one peptide 一个基因一条多肽链的概念
ic controls of metabolism 代谢作用的遗传控制
Variations in gene action and phenocopies 基因效应的变异与拟表型
一个基因一种障碍物
一个基因一种酶
一个基因一条多肽链
The conception: one gene one peptide
一个基因一条多肽链的概念
底物
中间产物1
中间产物2
产物
酶A
酶B
酶C
基因A
基因B
基因C
ic controls of metabolism
代谢作用的遗传控制
Variations in gene action and phenocopies基因效应的变异与拟表型
Expressivity: Degree of expression of a trait controlled by gene. A particular gene may produce different degrees of expression in different individuals表现度:某一基因型表达的程度。
rance: The percentage of individuals that show a particular phenotype among those capable of showing it. 外显率:表现某一特定表型个体的比例。
Phenocopy: anism whose phenotype (but not genotype) has been changed by the environment to resemble the phenotype of different (mutant) organism拟表型:环境因素有时引起非遗传的表型变化。
Regulation of gene expression in prokaryotes 原核生物基因表达的调节
An abbreviated pathway of gene expression in prokaryotes 简述
Operons: coordinately regulated units of gene expression 操纵子学说
The lactose operon in 大肠杆菌乳糖操纵子
An abbreviated pathway of gene expression in prokaryotes简述
Levels at which gene expression is regulated in prokaryotes
3. RNA stability
2. RNA processing 4. Translation 5. Posttranlation
DNA RNA transcript mRNA Protein Function
performed
by protein
Operons: coordinately regulated units of gene expression 操纵子学说
SG1
SG2
SG3
P1
R
P2
O
Operon
Structural genes
P1: promoter for regulator gene;
R: regulator gene;
P2: promoter for operon;
O: operator
Repressor
Effector molecule