文档介绍：Identification, Isolation, and
Characterization of Five Potential
Degradation Impurities in Candesartan
Cilexetil Tablets
&
Arivozhi Mohan1, , S. Shanmugavel1, Ajay Goyal1, B. R. Venkataraman2, D. Saravanan3
1 Torrent Pharmaceuticals Ltd., Analytical Development, Torrent Research Center, Gandhi Nagar 382428 Gujarat, India;
E-Mail: ******@
2 Post Graduate Department of Chemistry, Periyar . College (Autonomous), Tiruchirappalli 620 023, Tamilnadu, India
3 Department of Chemistry, National College, Tiruchirappalli 620001, Tamilnadu, India
Received: 12 October 2008 / Revised: 16 December 2008 / Accepted: 17 February 2009
cilexetil is converted to candesartan, an
angiotensin II receptor antagonist (ARA
Abstract II) which blocks the ability of angioten-
sin II to raise blood pressure by con-
Five impurities were observed when candesartan cilexetil tablets were subjected to stability stricting or squeezing arteries and veins
and forced degradation studies. These impurities were successfully isolated