文档介绍：BioInformatics (1)
What is Life All About : piling & self-assembling
Complementary surfaces
Watson-Crick base pair
(Nature April 25, 1953)
Life Science puting
Where do e from?
(computer & biological viral codes)
Over $12 billion/year
puter viruses
LoveBug
Set dirtemp =3D (2)
Set c =3D ()
(dirsystem&"\")
(dirwin&"\")
(dirsystem&"\LOVE-LETTER-FOR-")
regruns()
html()
spreadtoemail()
listadriv()
20 M dead (worse than
black plague & 1918 Flu)
AIDS - HIV-1
Polymerase drug resistance mutations
M41L, D67N, T69D, L210W, T215Y, H208Y
PISPIETVPV KLKPGMDGPK VKQWPLTEEK
IKALIEICAE LEKDGKISKI GPVNPYDTPV
FAIKKKNSDK WRKLVDFREL NKRTQDFCEV
anisms
Instructions Program Genome
Bits 0,1 a,c,g,t
Stable memory ROM,Disk,tape DNA
Active memory RAM RNA
Processing piler enzyme/Ribosome
Editing Editor tRNA
Environment Sockets,people Water,salts,heat
I/O AD/DA proteins
Monomer Minerals Nucleotide
Polymer chip DNA,RNA,protein
Replication Cut/Paste DNA replication
Sensor/In scanner Chem/photo receptor
Exciting Life ??
of RNA-based life: C,H,N,O,P
Useful for many species:
Na, K, Fe, Cl, Ca, Mg, Mo, Mn, S, Se, Cu, Ni, Co, Si
Elements
The Four Nucleosides of DNA
dA dG dC dT
A nucleoside is a sugar, here deoxyribose, plus a base
dA = deoxyadenosine, etc.
PYRIMIDINES
PURINES
Adenine
Guanine
Thymine
Cytosine
Uracil
BASES
Base Pairing
A nucleotide is a phospate,
a sugar, and a purine or a
pyramidine base.
The monomeric units of nucleic acids are called nucleotides.