文档介绍：Bioinformatics: Searching Sequence Databases and the Future of Bioinformatics Laurie Pepper MPS Thesis April 27, 2001 Introduction Bioinformatics: The science anizing and analyzing data. Molecular Biology Human Genome Project Data Tools Search algorithms Databases Bioinformatics Why this field is important Amount of data Searching Bioinformatics Genomics: DNA and RNA Proteomics: Protein structure and function Neuroinformatics: Brain structure position Molecular Biology DNA and RNA Bases Structure Protein Amino Acids Structure Molecular Biology DNA/RNA and proteins can be read as “strings”. Examples: (DNA) UGACUU (RNA) ACGHILMPST (Protein) Molecular Biology Genes - Why they are important Evolution Proteins - Gene products Do the work of life What we want to do with bioinformatics Algorithms Time Exact matching Finding ‘ABCD’ in ‘D’ Inexact matching Finding ‘ABCD’ in ‘ABBCDDAFBCD’ Multiple parison Computers and Programs Databases Search tools Substitution matrices Pairwise parison Multiple parison Databases Private vs. Public Public DNA/RNA GenBank Protein Swiss-Prot PROSITE