文档介绍：Pharm 202 “Digitally Enabled Genomic Medicine” and Its Role in Cancer Treatment
Phil Bourne
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-> Courses -> Pharm 202
Take Home Message
We are undergoing a revolution in our approach to treating disease
This has been driven by the human genome project and the technologies that go with it
A key element is the integration of information derived from genotype to phenotype
Much of this information is now digital rather than analog
This is much more than faster ways to develop drugs – it has to do with diagnostic treatments, preventive medicine, personalized medicine
Remember the two applications associated with cancer treatment
Today -
Overview of the revolution
Drug discovery specifically
The much more part as it relates to cancer
Improve the es of radiotherapy in treatment of breast and prostate cancer
Predictive gene signatures to define treatments for breast cancer
Approach Today
Rather than discuss specific papers of pleted we will take a broader perspective on proposed work on large scale projects that have the potential to impact people’s lives through digitally enabled genomic medicine
The grants we have studied are from Genome Canada and should be treated as confidential
Cell Biology
Anatomy
Physiology
Proteomics
Genomics
Medicinal
Chemistry
Organisms
Organs
Cells
Macromolecules
Biopolymers
Atoms & Molecules
SCIENTIFIC RESEARCH
& DISCOVERY
REPRESENTATIVE
DISCIPLINE
EXAMPLE
UNITS
MRI
Heart
Neuron
Structure
Sequence
Protease
Inhibitor
Electron
Microscopy
Migratory
Sensors
Ventricular
Modeling
X-ray
Crystallography
Protein
Docking
REPRESENTATIVE
TECHNOLOGY
Technologies
Training
Infrastructure
Digital vs Analog
The lower levels of plexity have always been digital – the higher levels analog
This made it very hard to correlate across biological scales
Some good examples of digital phenotypic data exist and it is now being collected in earnest
Lower Levels – Digital (sort of)
This digital image of cAMP dependa