文档介绍：Joshua Mostkoff UngerJoshua Mostkoff UngerDepartment puter ScienceDepartment puter ******@uiuc.******@ 491 - Seminar in Data Mining in CS 491 - Seminar in Data Mining in BioinformaticsBioinformaticsThursday, February 28, 2002Thursday, February 28, 2002REVIEW OF:REVIEW OF:Molecular Classification of Cancer: Molecular Classification of Cancer: Class DiscoveryClass Discovery and and Class PredictionClass Predictionby Gene Expression Monitoringby Gene Expression Monitoring"Molecular Classification of Cancer: Class Discoveryand Class Prediction by Gene Expression Monitoring"Golub, Slonim, Tamayo, Huard, Gaasenbeek, Mesirov, Coller, Lo, Downing, Caligiuri, Bloomfield, LanderAppears in Science Volume 286, October 15, 1999Whitehead Institute/MIT Center for Genome ...and Dana-Farber (Boston), St. Jude (Memphis), Ohio State...additional publications by same group shows similar technique applied to different disease modalities. Publication InfoPublication InfoCancer ClassificationCancer ClassificationClass Discovery: defining previously unrecognized tumor subtypesClass Prediction: assignment of particular tumor samples to already-defined classesGiven bone marrow samples:Which cancer classes are present among sample?How many cancer classes? 2, 4?Given samples are from leukemia patients, what type of leukemia is each sample (AML vs ALL)?Cancer of bone marrow?Myelogenous or lymphocytic, acute or chronic?Acute Myelogenous Leukemia (AML) vs Acute Lymphocytic Leukemia (ALL)?Marrow cannot produce appropriate amount of red and white blood cells?Anemia -> weakness, minor infections; Platlet deficiency -> easy bruising?AML: 10,000 new adult cases per year?ALL: 3,500/2,400 new adult/child cases per year?AML vs. ALL in adults & childrenLeukemia: Definitions & SymptomsLeukemia: Definitions & SymptomsLeukemia: Treatment & expected eLeukemia: Treatment & expected e?Diagnosis via highly specialized laboratory?ALL: 58% survival rate?AML: 14% survival r