文档介绍：Hindawi Publishing Corporation
Mediators of Inflammation
Volume 2013, Article ID 429207, 8 pages
/2013/429207
Research Article
Metformin Inhibits Expression and Secretion of
PEDF in Adipocyte and Hepatocyte via Promoting
AMPK Phosphorylation
Shumin Yang, Qiong Lv, Ting Luo, Lulu Liu, Rufei Gao, Shumei Chen, Peng Ye,
Qingfeng Cheng, and Qifu Li
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Street,
Chongqing 400016, China
Correspondence should be addressed to Qifu Li; ******@
Received 18 June 2013; Revised 7 August 2013; Accepted 9 September 2013
Academic Editor: Magdalena Klink
Copyright © 2013 Shumin Yang et al. This is an open access article distributed under the Creative Commons Attribution License,
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Objective. Pigment epithelium-derived factor (PEDF) plays an important role in obesity-induced insulin resistance (IR). The
study aims to investigate the effect of metformin, a widely used agent to improve IR, on PEDF production both in vivo andin
vitro. Methods. SD rats were divided into normal control group, high fat group (HF group), and me