文档介绍：Chapter 3 Metabolism of ponents in foods and pounds
In this chapter, we will learn:
1 Phase I reaction
2 Phase II reaction
3 Factors affecting the metabolic transformation of pounds
Periods 2
1 Phase I reactions
Concept: pounds are degraded into more polar derivatives by oxidation, reduction, hydrolysis,and other degradative reactions
Classification:
Oxidation
Microsomal oxidation---------liver
Mix function oxidase system: nicotinamide adenine denucleotide phosphate (NADPH), cytochrome reductase (flavoprotein [FAD]), cytochrome P-450 (also called terminal oxidase), O2,, nonheme sulfur iron protein
Aromatic oxidation
Aliphatic oxidation
Dealkylation
N-Dealkylation
And so on
Nonmicrosomal oxidation------cytoplasmand mitochondria
Dehydroxylation
Dehalogenation
Ring opening
Cycl