文档介绍：Chapter 6 Nutritional factors and carcinogenesis
In this chapter, we will learn
1 Ways of nutritional factors affecting tumor initiation and promotion
2 Effects of amino acids, vitamins, fat, carbohydrate and protein on tumor occurence
Periods: 2
1 The relationship between nutritional factors and tumor initiation:
Nutrition: requirement for the energy and metabolism of tumor cells
Vitamins and trace metals required by enzymes
Inhibition or enhance of the tumor promotion
Precursors of carcinogens
Fats are solvents of carcinogens
Nutritional status is closely related to the petence
The nutritional conditions can affect the intestinal flora, causing carcinogenesis.
2 Nutritional factors and carcinogenesis
Caloric intake
Excess caloric intake over caloric expenditure may cause endocrine dysfunction, resulting in obesity
Increase of obesity increase in mortality from cancers
2 Nutritional factors and carcinogenesis
Dietary excesses or deficiency of proteins
Animal protein --------intestinal cancer mortality
The level of proteins affects the enzymes in liver and ans
2 Nutritional factors and carcinogenesis
Amino acids
Lysine-deficient or cystine deficient rats --------inhibition of spontaneous mammary tumor development
Phenylalanine –deficient diets: inhibition of tumor formation
2 Nutritional factors and carcinogenesis
Effects of protein and amino acid deficiency on the immune system
2 Nutritional factors and carcinogenesis
Effects of dietary lipids:
PUFA: conflicting studies
Facilitating carcinogen absorption and modifying lipid distribution
2 Nutritional factors and carcinogenesis
anic nutrients:
Metallic nutrients and other anic elements are closely related in function to vitamins
Magnesium
Manganese
2 Nutritional factors and carcinogenesis
Vitamins
Functions of vitamins in general
Coenzymes in many metabolic reactions
Involving in many cellular reactions
Modulating metabolic reactions involved in biosynthesis
Influence on