文档介绍：ANCA相关性小血管炎及其肾损害
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Anti-Neutrophil Cytoplasmic Autoantibodies (ANCA)
P-ANCA Perinuclear Pattern
Anti-myeloperoxidase
MPO-ANCA
C-ANCA Cytoplasmic Pattern
Anti-Proteinase 3
PR3-ANCA
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Large Vessel Vasculitis
Giant Cell Arteritis
Takayasu Arteritis
Medium Vessel Vasculitis
Polyarteritis Nodosa
Kawasaki Disease
Small Vessel Vasculitis
ANCA-Associated Vasculitis
Microscopic Polyangiitis
Granulomatosis with Polyangiitis (Wegener’s)
Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss)
Immune Complex Vasculitis
Anti-GBM Disease
IgA Vasculitis (Henoch-Schönlein)
Cryoglobulinemic Vasculitis
Hypocomplementemic Urticarial Vasculitis (Anti-C1q Vasculitis)
Variable Vessel Vasculitis (Cogan’s, Behcet’s, etc.)
Single Organ Vasculitis (cutaneous SVV, primary CNS vasculitis, etc.)
Vasculitis Associated with Systemic Diseases (. Rheumatoid, Lupus, Sarcoid, etc.)
Vasculitis Associated with Probable Etiologies (. HBV, HCV, drug, cancer, etc.)
2011 Chapel Hill Consensus Conference Vasculitis Nomenclature
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Aorta
Arteries
Arteriole
Capillary
Venule
Vein
ANCA Associated Vasculitis
Small Vessel Vasculitis
Eosinophilic Granulomatosis with Polyangiitis
(Churg-Strauss)
ANCA Associated Vasculitis
MPA
GPA
EGPA
AAV
SVV
PICGN
Microscopic
Polyangiitis
vasculitis with
no asthma or
granulomas
Granulomatosis with Polyangiitis
(Wegener’s)
granulomas
and no
asthma
eosinophilia,
asthma and
granulomas
glomerulonephritis
Pauci-immune Crescentic Glomerulonephritis
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ANCA（抗嗜中性白细胞胞浆抗体)，为ANCA相关小血管炎(AASV)(国内常称原发性小血管炎)的特异性血清学诊断工具
我国小血管炎并不少见，北大医院近5年内诊断ANCA（＋）小血管炎1000余例
我国该病漏诊或误诊在基层或落后地区仍相当严重，治疗不规范，应进一步重视ANC