文档介绍：P rimary extranodal non-Hodgkin’s lym- p ho mas a c c ount f or 10-30% of all non- Hodgkin’s lymphomas. The - mon site of extranodal lymphomas is the stom- ach where they represent less than 5% of all malignancies. While both the incidence and the mortality of gastric cancer have been decreasing o ver the past several years in Western countries, p r imar y gastric lymphomas (PGL) have been steadily rising over the same period (from t o 7 p e r mil lio n p eople). 1-5 The optimal management of PGL has yet to be de?ned. Up to now surgery has been regarded as essential because it enables diagnosis and accu- r at e stag ing , r e duces the risk of bleeding and/or perforation after chemotherapy and/or radio- therapy, and cures some patients or has debulk- ing value in the others. 6-13 Of late, the need for surgery as a diagnostic tool has been decreasing because a histological diag nosis can b e obtained by endoscopic biop- sies in mo r e than 90% o f cases. 1,14,15 Staging performed with non-invasive meth- o ds is unab le t o dist inguish b etween stage I and stage II1, but this distinction has no therapeutic relevance because these two stages behave simi- larly. 14,16 Correspondence: Dr. Carla Rabbi, Department of Medical Oncology, Ospedale Carlo Poma, Viale Albertoni, 1, 46100 Mantua, Italy Received May 15, 1995; accepted November 22, 1995. STOMACH PRESERVATION IN LOW- AND HIGH-GRADE PRIMARY GASTRIC LYMPHOMAS: PRELIMINARY RESULTS Carla Rabbi, Enrico Aitini, Giovanna Cavazzini, Maurizio Cantore, Maria Enrica Forghieri,* Franca Pari, Donatella Zamagni, Andrea Mambrini, Marcello Amadori, Franco Smerieri Department of Medical Oncology and *Department of Immunohematology, Ospedale Carlo Poma, Mantua, Italy original paper Haematologica 1996; 81:15-19 ABSTRACT Background. The optimal management of primary gastric lymphomas has yet to be de?ned. In the past surgery was advocated as the optimal ?rst step for patients with PGL. Recently, an increas- ing number of studies