文档介绍：1
Granulocytic leukemia
myelocytic leukemia; CML
myeloblastic leukemia;AML
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1： Chronic myelocytic leukemia
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chronic myelocytic leukemia (CML)
Malignant clonal hematopoietic stem cell disease
White blood cell count
Can see the various stages
Granulocytes Mainly in late stage
Spleen significantly
increased Even splenomegaly
More than 90% exists Ph ' chromosome And BCR / ABL Fusion gene
【clinical manifestation 】
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Staging of the International Bone Marrow Transplant Registry group of CML
In phases
clinical manifestation
chronic phase No obvious symptoms
Accelerated phase or blast phase characteristics
accelerated phase to control the number of leukocytes in the
conventional treatment
doubling time of less than 5 days
marrow or blood the Central Plains granulocytes ≥
10%
in bone marrow or blood Zhongyuan +
promyelocytes ≥ 20%
basophils + eosinophils ≥ 20%
or thrombocytopenia not improve after conventional
treatment
platelet count increased
chromosomal abnormalities involving new clone
progressive enlargement
chloroma occurred or bone marrow fibrosis
acute transformation phase
Granulocytes in bone marrow or blood Zhongyuan + promyelocytes ≥ 30%
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Chronic myelocytic leukemia
chronic phase
Three phases accelerated phase
acute transformation phase
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Chronic phase
Early symptoms : occasionally found blood abnormalities , splenomegal