文档介绍：门冬胰岛素联合二甲双胍对妊娠期糖尿病患者妊娠结局的临床分析
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[摘要] 目的 探討门冬胰岛素联合二甲双胍治疗妊娠期糖尿病（GDM）的临床效果。 方法 便利选取2018年5月—2019年5月该院收治的82例GDM患者，按随机数字表法分为两组，各41例。对照组予以门冬胰岛素治疗，观察组加用二甲双胍治疗。比较两组用药前与分娩前血糖水平、胱抑素C（Cys C）及同型半胱氨酸（HCY）水平，并对比两组妊娠结局。结果 治疗前，两组FPG、HbA1c、2 hPG相比，差异无统计学意义（t=，，，P=，，）;治疗后，观察组FPG、HbA1c、2 hP***平为（±）mmol/L、（±）%、（±）mmol/L，低于对照组的（±）mmol/L、（±）%、（±）mmol/L，差异有统计学意义（t=，，，P<）;治疗前，两组Cys C及HCY水平相比，差异无统计学意义（t=，，P=，）;治疗后，观察组Cys C、HCY水平为（±）mg/L、（±）μmol/L，低于对照组的（±）mg/L、（±）μmol/L，差异有统计学意义（t=，，P<）;%，%，差异有统计学意义（χ2=，P=）。 结论 门冬胰岛素联合二甲双胍治疗可稳定GDM患者血糖水平，降低Cys C、HCY水平，减少不良妊娠结局。
[关键词] 妊娠期糖尿病;门冬胰岛素;二甲双胍;妊娠结局;血糖水平
[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742（2020）10（b）-0109-03
[Abstract] Objective To explore the clinical effect of insulin aspart combined with metformin in the treatment of gestational diabetes mellitus （GDM）. Methods A total of 82 GDM patients admitted to the hospital from May 2018 to May 2019 were convenient selected and divided into two groups according to the random number table method， with 41 cases in each group. The control group was treated with insulin aspart， and the observation group was treated with metformin. The blood glucose levels， Cys C （Cys C） and homocysteine （HCY） levels were compared between the two groups before medication and before delivery， and the pregnancy outcomes of the two groups were compared. Results Before treatment， there was no significant difference between the two groups of FPG， HbA1c， 2 hPG （t=， ， ， P=， ， ）; after treatment， the observation group FPG， HbA1c， 2 hPG levels were （±）mmol/L， （±）%， （±）mmol/L， lower than the control gro