文档介绍：()在结肠组织炎性细胞内的表达情况。Wrestem ::A 组:,B组:,C组:,D组:,评分示B组与C组、D组比较差异有统计学意义(尸<)。C组与D组比较也有统计学意义(尸<).:B组小鼠结肠炎症主要累及黏膜和黏膜下层,少数可达浆膜层,结肠黏膜不完整,可见多灶性浅溃疡,大部分腺体被破坏,腺体正常结构丧失,可见密集炎性细胞浸润。C组、D组小鼠结肠腺体破坏较轻,结构基本恢复正常,炎性细胞浸润深度较B组浅,炎性细胞数量也显著减少。B组的评分()明显高于C组、D组的评分(、),差异有统计学意义(尸<);.C组的评分低于D 组,差异有统计学意义(P<)、:B组 n师-Q、IL-6的浓度分别为[()pg/ml、()p咖l】,明显高于C组[()p∥ml、()p咖l】、D组[()p咖l、()pg/ml】的浓度,B组与C组、D组比较差异有统计学意义(尸< ).C组与D组比较,,(P<)。:A组在胞质中偶有表达,B组胞质和胞核均呈现强表达,C组在胞浆表达,胞核中也有少许表达,D组胞质和胞核中均有表达,但弱于B组。B组评分() 与C组()、D组()比较差异有统计学意义(尸<), C组与D组比较差异有统计学意义(尸<)。 :W|estemblot显示B组结肠组织中11(B0【蛋白水平与A组相比明显下降,C 组、D组蛋白水平与B组相比明显升高,差异有统计学意义(尸<)。结论:1、细胞因子、NF一1(B在UC的发病中起着重要作用;2、姜黄素可以有 2 levels of TNF—a levels and IL一6in group B were(-)pg/ml、(-)pg/mlrespectively,significantly higher thanthose ofgroup C 【(-)pg/ml and(-)pg/ml】respectively and those of group D[(- 5)pg/mland(-)pg/ml】respectively(all尸< 1),and the levels of IL一6ingroup C was lessthangroupD(尸<)。 NF— scores: The immunohistochemistry demonstrated the NF— expressed in cytoplasm and cytoblast ofgroup B,andrarely expressed incytoblast ofgroup C,also theNF—rd3 expressed incytoplasm andcytoblast ofgroup D but the expression was lowerthangroup scores ofgroup Bwas(-) evidentlyhigher than thoseofgroup C(-)and group D(+) ( 1),and the scores ofgroup Cwas lowerthangroup D(P<)。 expression :The western blotdemonstrated thatthelevelof Ir,Baingroup Bwas lessthangroup CandgroupD(P<).Conclusion:Curcumin haspositive effectintreating DSS-induced colitis inmice and theeffectissuperior to reduces colonic