文档介绍：Epilepsy Research 65 (2005) 153–159
Ketogenic diet increases calbindin-D28k in the hippocampi
of male ICR mice with kainic acid seizures
Hae Sook Noh a,1, Sang Soo Kang a,1, Dong Wook Kim b, Young Hee Kim a,
Chang Hwan Park a, Jae Yoon Han a, Gyeong Jae Cho a, Wan Sung Choi a,∗
a Department of Anatomy and Neurobiology, Institute of Health Science, College of Medicine, Gyeongsang National University,
92 Chilam-dong, Chinju, Kyungnam 660-751, Republic of Korea
b Department of Pediatrics, Inje University Ilsan Paik Hospital, Goyang, Gyeonggi 411-706, Republic of Korea
Received 21 December 2004; received in revised form 12 February 2005; accepted 19 May 2005
Available online 19 July 2005
Abstract
The ketogenic diet (KD) increased the expression of calbindin-D28k (CB) in the interneurons of the hippocampus compared
with the normal diet (ND)-fed mice. Also, 2 days after kainic acid (KA) administration, numerous CB-expressing astrocytes
were found in the KD-fed mice compared with those of the ND-fed mice. These results suggest that the neuroprotective effect
of the KD on the KA-induced toxicity may be, in part, mediated via an increased expression of CB.
© 2005 Elsevier . All rights r