文档介绍：.34- 广东化工 n 2007年第4期第34卷总第168期 2,4,5一三羟基苯丁***的合成研究唐源胜,赵丽冰,林杰,黄志勇(广东省食品工业研究所广东省食品上业公共实验室,广东广州510308) 【摘要1讨论了2,4,***(n豫P)的储化合成方法。,在惰性气体保护和嵇襁荆越Cb静存在下,在芳番烃与承组残睁二元潞台溶荆中,与丁裴爵厦应,经过芳番烃洛剃瓣后处理,可班得到2,4,5一兰羟基苯丁***(THBP).产率最高达86%,该方法的优点在于原料易得,操作条件简单,易于控制,收事稳定,产品质量高,成本低。,5-三羟萋苯丁鬻(THBP);-三羟基苯;催讫合成 Study on Catalytic Synthesis of2,4,5·Trihydroxybutyrophenone Tang Yuansheng,Zhao Libing,Linjie,Huang Zhiyong (Guangdong Food Industry Institute,Guangdong FoodIndustry InstitutePublicLaboratory,Guangzhou 510308,China) Abstract:A new method forcatalyticsynthesis of2,4,5一WihydroxybutyropHenone fr扣3P)WaS ,-trihydroxybenzene WaS used mercially available。Byusing amixture ofaromatic hydrocarbon and water asabinary solvent, reaction of 1,-trihydroxyberlzene with butyricanhydride Was carriedout抽the presence of acatalyst(ZnCl2,A1C13 OF SOCl2), 2,4,5·trihydroxybutyrophenone was obtained inyields of80~86%with theadvantages ofeasy control,stableyield,high pt、oductquality andlow Keywords:2,4,5一trihydroxybutyrop;1,2,,l-ttihydroxybertzene;catalytic synthesis 2,4,5一兰羟基苯丁酗(THBP)是一种良好的抗氧化荆,广泛应用于食甩油脂、饮料、化妆鼎及食鼹包装材辩fh31中。,"13IBP与柠檬酸配合可有效地稳定黄油。弼时THBP也是石蜡的佬盥抗氧位荆。其活性是BHT的兰倍。关于它的制备方法,最近十几年才较多地吐l现在世雾磬蓬的文献报道中,在瓣内港米见捂关报道。_l实验部分 OH ,温度计未经校正;MS朋 DSQ(Thermo)型质jl}仪;‘H NMR/NOVA一400M型超导核磁共振谱仪溅定,以CDCl3为溶赉』,TMS为内标;蛏辨光谱尉