文档介绍：FEBS Letters 583 (2009) 3811–3816
journal homepage:
Review
Multiple routes of protein transport from endosomes to the trans Golgi network
Suzanne R. Pfeffer *
Department of Biochemistry, 279 Campus Drive B400, Stanford University School of Medicine, Stanford, CA 94305-5307, USA
article info abstract
Article history: Proteins use multiple routes for transport from endosomes to the Golgi complex. Shiga and cholera
Received 28 August 2009 toxins and TGN38/46 are routed from early and recycling endosomes, while mannose 6-phosphate
Revised 27 October 2009 receptors are routed from late endosomes. The identification of distinct molecular requirements
Accepted 27 October 2009
for each of these pathways makes it clear that mammalian cells have evolved more complex target-
Available online 29 October 2009
ing mechanisms and routes than previously anticipated.
Edited by Antonella De Matteis Ó 2009 Federation of European Biochemical Societies. Published by Elsevier . All rights reserved.
Keywords:
Endosome
Golgi
R