文档介绍：咪唑斯汀缓释片的释放度研究孙建绪 1刘亚琴 2胡音 1高永良 1 ( 1军事医学科学院毒物药物研究所,北京 100850 ; 2国家发改委药品价格评审中心,北京 100045 ) [摘要]目的:对制备的咪唑斯汀缓释片进行体外释放度研究。方法:采用比较法对不同的释放介质进行考察。结果:本片在 盐酸、蒸馏水和 磷酸缓冲液中 2 小时后的体外释放度大于 60% 、5 小时大于 80% 。结论:本品在上述三种介质中体外释放基本一致,其释放度不受释放介质 pH值的影响,达到了设计要求。[关键词] 咪唑斯汀缓释片处方释放度含量测定[中图分类号] [文献标识码] [文章编号] In vitro evaluation of Sustained-release Tablet of Mizolastine S UN Jian-xu 1 LIU Ya-qin 2 HU Yin 1 GAO Yong-liang 1 (1. Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850 , China; 2. Evaluation Center of Drug Pricing National Development and mission , Beijing 100045, China) [Abstract] Objective : To evaluate dissolution in vitro of sustained-release tablet of mizolastine. Methods : The dissolution behaviors of sustained-release tablet of mizolastine, were evaluated in three different medias as ,purwater PBS (pH )solution. Results : In vitro evaluation indicated that it can release more than 60% after two hours and more than 80% after five hours in ﹒L -1 HCL, pure water, PBS() solution Conclusion : Sustained-release tablet of mizolastine were expected to sustained-release effectiveness on this formulation and technology, and have a good stability; the developmental research of sustained-release tablet of mizolastine support quantity of data for pharmaceutical engineering research. The release behaviors in different medias w