文档介绍：黑龙江中医药大学硕士学位论文缩略语表缩略语 CAMP DU EGF GMBF GU HP MDA N0 NSAID PU PG PPI PUFA SOD 英语全称 Cyclic adenosine monophosphate Duodenal ulcer EpidermaI growth factor Gastric mucosal blood now Gastric ulcer Helicobacter pylori Malondialdehyde Nitrogen monoxidum Nonsteroid anti—inflammatory drugs Peptic ulcer Prostaglandin Proton pump inhibitor Polyunsaturated fatty acid Superoxide dismutase 中文名称环腺苷酸卜■指肠溃疡表皮生长因子胃粘膜血流量胃溃疡幽门螺旋杆菌丙二醛一氧化氮非类固醇抗炎药物消化性溃疡前列腺素质了泵抑制剂多不饱和脂肪酸超氧化物歧化酶黑龙江中医药大学硕士学位论文中文摘要本课题旨在通过古今文献研究、动物实验研究及药理研究, 观察四逆散是否具有抗胃溃疡作用,阐明其抗溃疡的科学合理性, 并对其作用机理进行初步探讨。中医认为胃溃疡病因病机多与情志不遂,特别是忧思恼怒等,引起肝气郁结,疏泄失常,木来克土有关,故在本病的辨证治疗上,多用透邪解郁,疏肝理脾法治疗,每能取得良好效果。本课题采用应激法、醋酸涂抹法及幽门结扎法复制大鼠消化性溃疡模型,在药效学基础上探讨四逆散抗溃疡的作用机制。结果表明四逆散对多种方法所致的急、慢性胃溃疡均有明显的治疗及预防作用。 c【含量(6一keto—PGFl 0c)、胃组织超氧化物歧化酶(SOD)水平和降低胃液总酸度、抑制胃蛋白酶活性、胃组织丙二醛(MDA)水平有关,对一氧化氮(N0)含量无明显影响。说明四逆散可能通过抑制损伤因子与增强防御因子两个环节发挥作用。不仅验证了四逆散组方用药的合理性和科学性,也为进一步认识中医“疏肝理脾”的作用机制提供了一定的实验依据,同时对于指导临床治疗胃溃疡中药用药及开发新药等,都具有一定的参考价值。关键词: 四逆散胃溃疡药效学作用机理黑龙江中医药大学硕士学位论文 ABSTRACT This subject aims at observing ifsini powder has the effect of anti-ulcer and elucida{ing itsscientific rationality ofanti—ulcer,and initial discuss itseff色ctive mechanism through ancient and modern document inVestigation, empirical study and pharmacology investigation. Traditional Chinese medicine considers that eti0109ical factor and pathogenesis of gastric uIcer are related with disorder of emotionaI actjVities, especiaI inVolVing worry and angry, which leads to stagnation of liver—qi, dysfunction of smoothing and dispersing qi, and wood restraining earth. So based on the differentiation of symptoms and treatment,it should be treated bv reJieVing stagnatjon and smoothhlg the , as well as regulating the spleen,whose effect isobvious. rat peptic ulcer model by means of pylorjc 1jgature, acetic acid daub and irritable methods. Approach sini powder anti—ulcerative mechanism ofaction based on pharmacodynamics. The conclusion demonstrates with regard to a11kinds ofchronic and acute pe