文档介绍：Antimicrobial Activity of Some 13-Alkyl Substituted Protoberberinium Salts
Kinuko Iwasa,Miyoko Kamigauchi,Makiko Sugiura,and Hiroaki Nanba
Abstract: Several 13-alkyl substituted analogs of berberine and palmatine were found to be highly active against two types of us aureus (S1 and S2)of different origin. The most active 13-hexylberberine was 8 times more active (against S1)and the same order active (against S2)as kanamycin -Hexylpatmatine displayed an activety against (S1)4 times greater than that of kanamycin sulfate. The activities of 13-hexylberberine against two types of were 64 and 128 times greater than those of the clinically used alkaloid berberine. Additionally two hexyl derivatives possessed antifungal activity.
Key words:13-Alkylrotoberinium salts, antimicrobial activity, antifungal activity.
Introduction
The quaternary is oquinoline alkaloid berberine(1),isolated from a variety of plants, is widely used in Asia as a drug due to its antimicrobial activity. In Japan, berberine and the extracts of the dried rhizomes of Coptis japonica Makino (Ranunculaceae) and the dried bark of phellodendron amurense Ruprecht (Rutaceae)are widely used as a stomach tonic. In a previous paper the antibacterial activity of berberine analogs has been reported (1).In brief, the 13-methyl derivative(2) ,the 13-ethyl analog(3),and the 13-ethyl-9-ethoxy hom