文档介绍：Advanced Drug Delivery Reviews 58 (2006) 1274–1325
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Mathematical modeling and simulation of drug release from
microspheres: Implications to drug delivery systems ☆
⁎
Davis Yohanes Arifin a, Lai Yeng Lee a, Chi-Hwa Wang a,b,
a Molecular Engineering of Biological and Chemical Systems Program, Singapore–MIT Alliance, 4 Engineering Drive 3,
Singapore 117576, Singapore
b Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4,
Singapore 117576, Singapore
Received 13 July 2006; accepted 4 September 2006
Available online 26 September 2006
Abstract
This article aims to provide prehensive review of existing mathematical models and simulations of drug release from
polymeric microspheres and of drug transport in adjacent tissues. In drug delivery systems, mathematical modeling plays an
important role in elucidating the important drug release mechanisms, thus facilitating the development of new pharmaceutical
products by a systematic, rather than trial-and-error, approach. The mathematical models correspond to the known release
mechanisms, which are classified as diffusion-, swelling-, and erosion-controlled systems. Various practical applications of
these models which explain experimental data are illustrated. The effect of γ-irradiation sterilization on drug release mechanism
from erosion-controlled systems will be discussed. The application of existing models to nanoscale drug delivery systems
specifically for hydrophobic and hydrophilic molecules is evaluated. The current development of drug transport modeling in
tissues putational fluid dynamics (CFD) will also be described.
© 2006 Elsevier . All rights reserved.
Keywords: Release mechanism; Polymeric system; Diffusion; Swelling; Erosion; Irradiation; Transport; Tissue; Brain; Computational fluid
dynamics
Contents
1. Introduction .................................................... 1275
2. Mathematical models for diffus