Oral Solid Dosage Forms 1.ppt

文档介绍：11/11/2017
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Types of Excipients
Filler/Diluent
Disintegrant
Solution Binder
Dry Binder
Glidant
Lubricant
Antiadherent
Color
Coating
Protective Agents
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Related Chapters
8: Physicochemical properties
9: Solid State Properties
10: Particle Size Analysis
11: Particle Size Reduction
12: Particle Size Separation
13: Powder Flow
24: Powders and Granules
25: Granulation
26: Drying
27: Tablet paction
28: Coating of Tablets and Multiparticulates
29: Hard Gelatin Capsule
30: Soft Gelatin Capsule
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Oral Solid Dosage Forms
Physicochemical Characteristics
Biological Characteristics
Pharmaceutical Excipients
Pharmaceutical Manufacturing Process
Stability Problems of Oral Solid Dosage Forms
Biopharmaceutical Considerations
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Physical Characteristics
Appearance
Tablets
Capsules
Powders
Physicochemical Characterization
Rapid Release
Sustained/Controlled Release
Enteric Coating
Other Coating
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Physicochemical Characteristics
Thermodynamically Stable
Powder
Less Thermodynamically Stable
Tablet
Capsule
When something is themodynamically stable, it usually maintains its physical form.
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Physical Characteristics
Powder
Solid coarse dispersion
Capsules
Powders
Granules
Coated granules
Tablets
Single Layer
Multiple Layers
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Physical Characteristics
Powder
Apparent taste
Apparent smell
Capsules
Slower drug release
Less taste or smell
Tablets
Variable drug release rate
Significant taste or smell
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Biological Characteristics
Powder
Rapid onset of pliance problem
Capsules
Slower onset of action
Sustained drug release
Easier to dose drugs with bad taste/smell
pliance problem
Slower onset of action
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