文档介绍：Drug Discovery Today: Disease Models Vol. 5, No. 2 2008
Editors-in-Chief
Jan Tornell – AstraZeneca, Sweden
DRUG DISCOVERY Andrew McCulloch – University of California, SanDiego, USA
TODAY
DISEASE
MODELS Non-human primate models of human disease
Xenotransplantation
Henk-Jan Schuurman1,2
1Spring Point Project, 121 South 8th Street, Suite 825, Minneapolis, MN 55402, USA
2Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, 420 Delaware Street SE, MMC 195, Minneapolis,
MN 55455, USA
Xenotransplantation (the transplantation of viable
Section Editors:
organs, tissue or cells from one to another species) is Margreet Jonker, Michel Vierboom and Bert ’t Hart –
proposed to alleviate the shortage of donors in repla- Biomedical Primate Research Centre BPRC, Rijswijk,
The Netherlands
cing dysfunctional organs/cells in patients with end-
stage organ failure. There are in vitro and in vivo models
simulating distinct aspects of the procedure. The best A porcine-derived xenotransplantation product is a com-
comprehensive model is