文档介绍：Relationships between Inhibition Constants, Types of
Inhibition and IC50
Calculation parison on IC50 of Two Model Tyrosinase Inhibitors
Hairong Mao1, Jiangang Xie1, Qimeng Zhang2, Xinyu Lü3, Shubai Li2,*
1 Department of Chemistry, Zhengzhou Teachers College, Zhengzhou, China
2 Department of Chemical Engineering Technology, Changzhou Institute of Engineering Technology, Changzhou, China
3 Institute of Fine Chemicals, Jiangsu Polytechnic University, Changzhou, China
* Corresponding author. E-mail: ******@email.

Abstract—Calculating methods for inhibitor concentration (IC50) inhibiting biological or biochemical function. Often, the
leading to 50% activity lost (for diphenolase activity) of a pound in question is a drug candidate. This quantitative
petitive inhibitor (the trifluoromethyl-containing measure indicates how much of a particular drug or other
1,2,3-triazole, TF-TA) and a novel mixed inhibitor ([E]-4-(1- inhibitors needed to inhibit a given biological process by half.
imidazoylmethyl) cinnamic acid (ozagrel) were derived on the It monly used as a measure of antagonist drug potency in
basis of ics of tyrosinase inhibition. These methods were pharmacological research. However, it appears not to have
applied to calculate IC50 values of the two tyrosinase inhibiting been noticed previously that there is a very simple relationship
comp