文档介绍：Quantitative Modeling Effects of Nucleosome on
Transcription Factor-DNA Interactions
Qian Xiang, XianHua Dai
Department of Electronics & Communications Engineering
School of Information Science and Technology, Sun Yat-Sen University
Guangzhou, PR China
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Abstract—Transcription factor-DNA interactions play a central focused solely on the contribution of TFs and did not consider
role in transcriptional control. These bindings are stochastic the effect of nucleosomes [9, 16-18]. The paper of Liu [5] have
processes and regulated by the nucleosomes in vivo. However, taken account of the nucleosome occupancy in addition to TFs
current models tend to neglect the nucleosomes and regard the and significantly improved the prediction of Leu3-DNA
binding as a set of binary cases. putational model is interactions in vivo. The work of Segal [12, 14] have employed
presented here to address the issues. It integrates TF bindings to a thermodynamic model to explore the importance of interplay
nucleosomal and naked DNA in a quantitative manner and between nucleosomes and TFs in transcriptional control and
results in continuous binding probabilities along the genome. The expression prediction. The nucleosome occupancy information
predictive ability of the model was applied to rationalize the was also used to assist identification of TFBS in [6