文档介绍：VAMA: a versatile web-based tool for variability
analysis in multiply-aligned amino acid sequences
VAMA:Variability Analysis of Multiple Alignments
Aditi Gupta, Aridaman Pandit and Somdatta Sinha
Mathematical Modeling putational Biology Group, Centre for Cellular and Molecular Biology (CSIR)
Hyderabad 500007, India
Email:
Abstract—Quantifying residue variability at each column in a variability in multiple alignments based on different scoring
multiple sequence alignment of amino acids helps in indicating methods are plex [9], and none of them consider all
their similarities, and is useful to highlight information about the the above-mentioned position-specific features in proteins [10-
significances of each position from the perspective of their 15]. A tool for scoring variability in multiply-aligned amino
structure, function, and evolution. It is ing increasingly acid sequences, that is simple but address this specific feature
clear that the groups of amino acids that allow conserved of allowing different conservation groups, is highly desirable.
replacement vary with the position of the residue in the protein.
Most multiple alignment algorithms cater to general users and We have developed a web-based program (VAMA) that
hence do not address this specific feature. A tool for scoring quantifies the variability of the residues a