文档介绍：Robustness and nonlinear dynamic analysis for trp
operon and optimization of tryptophan production
An integrated model considering gene regulation, genes interaction and product excretion
Yaqin Sun Xiaojia Mu Zheng Li Hu Teng ZhiLong Xiu *
Department of Bioscience & Biotechnology
Dalian University of Technology
Dalian, P. R. China
Corresponding author: ******@dlut.
Abstract—The tryptophan operon (trp operon), paradigm for participating in the biosynthetic pathway from chorismic acid
repressible operons, is regulated by three different negative- to tryptophan. Initiation of transcription is controlled by the
feedback mechanisms of repression, transcription attenuation interaction of the tryptophan repressor with its target site on
and enzyme inhibition. Initiation of transcription is controlled by the DNA [1]. The tryptophan repressor is the protein product
the interaction of the tryptophan repressor with its target site on of trpR and contains tryptophan binding site which can bind
the operator. Moreover, the interaction among the regulator tryptophan [2]. The synthesis of inactive repressor increases
genes, the operator genes and the structure genes and excretion when tryptophan is growth limiting because the repressor
of tryptophan play an important factor according to previous autoregulates its own synthesis [3].The repressor-end