文档介绍：Adhesive and In Vitro Release Properties of the
Konjac annan and Xanthan Gum Mixture Gel
Film
ZHANG Ying-qing, XIONG Wei-de, MI Zhi-yuan, MA Zhuo,LI Xiao-li
Bioengineering College
Hubei University of Technology
Wuhan, China
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Abstract—Purposes: To study the adhesive and the in vitro
release properties of a mixture gel film prepared with two kinds II. MATERIALS AND METHODS
of natural harides – konjac annan and xanthan
gum. Methods: The optimal formula was investigated by the A. Materials and Instruments
quadratic regression rotatable orthogonal design with adhesive Konjac refined powder was purchased from Wuhan Qunyi
force as the evaluated parameter. Its in vitro release behavior Konjac Production Co. China; Xanthan gum (XG) was
was studied by the in vitro accumulative released curve with purchased from Shan Dong Reagent Co. China; Glycerol,
aciclovir as the model medicine. Results: By predication and Tween-80, ethyl alcohol and liquid paraffin were purchased
verification, the optimal formula for film-forming was from Shanghai Chemical Reagent Co. China.
determined as follows: 50 mL of mixture gel of 1 %(w/w)
konjac annan and 1 % (w/w) xanthan gum solution at the UV-visible spectrophotometer (UV2550, Savant Instrument
ratio of :1 (v/v), added mL of glycerol and mL of Co. Ltd. ); Intelligent