文档介绍：Morphological changes of chondrocytes pressed
articular cartilage using polarized light microscopy
Ekrem Cicek1,2, Farid Badar1, Jia Li3, Xiaoyu Tian3, Yang Xia1
1Department of Physics and Center for Biomedical Research, Oakland University, Rochester, MI 48309, USA
2Department of Physics, Faculty of Arts and Science, Mehmet Akif Ersoy University, Burdur, Turkey
3Department of Electrical puter Engineering, Oakland University, Rochester, MI 48309, USA
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Abstract— The orientation and shape of chondrocytes in matrix. An external load will elevate pressive
compressed articular cartilage were studied quantitatively by stress and force some water out of the GAG matrix until the
polarized light microscopy (PLM) at µm pixel-resolution. increased repulsion from the pact GAGs
The morphological changes of the cell shapes, the cell ultimately reaches a new equilibrium with the external load.
orientation, and the territorial matrix surrounding the Such behaviors are best described by some theoretical
chondrocytes in articular cartilage were quantified.
models of articular cartilage such as the biphasic theory,
Keywords: Chondrocyte, articular cartilage, compression, which considers collagens/proteoglycans as solid and
polarized light microscopy water/small-ions as fluid. The fluid phase can redistribute
itself under loading, th