文档介绍：ics of Metronidazole Colon-targeted
Capsules in dogs
Li Hui1, 2, Zheng Xiaoxiang1, Zhang Shaomin1
1(College of Biomedical Engineering and Instrument Science, Yuquan Campus, Zhejiang University
Hangzhou, Zhejiang Province, . China, 310027)
2(College of Biological and Chemical Engineering, Zhejiang University of Science and Technology
Hangzhou, Zhejiang Province, . China, 310023
zjulihui@)
Abstract—In order to evaluate the results of slow-release of
metronidazole colon-targeted capsules , this study was II. MATERIALS AND METHODS
undertaken to examine the ics of metronidazole
colon-targeted capsules, normal reference tablets and colon A. Animals and Chemicals
delivery capsules in dogs. The level of metronidazole and its All facets of animal care and use in our experiment met the
metabolites in serum simultaneously were measured by high requirements of the Chinese Code of Practice for the Care and
performed liquid chromatography (HPLC). According to the Use of Animals for Scientific Purposes. Experiments were
serum drug concentration-time curves of metronidazole, performed on adult female Pit Bull Terrier, obtained from
ic parameters were calculated. The results Zhejiang Center of Laboratory Animals (Grade II, Certificate
indicated that the ic parameters of colon-targeted No 2001001), weighing 24~26kg.
capsules parable to those of