文档介绍：Molecularly imprinted polymer microspheres
prepared by precipitation polymerization for the
binding and recognition of roxithromycin
Jin-yang Yu, Xiao-ling Hu, Da-peng Li, Hong-li Wang
Department of Applied Chemistry, School of Natural and Applied Science, Northwestern Polytechnical University,
Xi’an 710129, PR China
mercury3302@
Abstract—In the presence of a template molecule, with less frequent administration, which is regarded as an
roxithromycin (RM), novel molecularly imprinted advantage in clinical settings. Because of these advantages,
polymer (MIP) microspheres were prepared by one-step roxithromycin is extensively applied for prevention and
precipitation polymerization using methacrylic acid treatment of bacterial infections in medical and veterinary
(MAA), ethylene glycol dimethacrylate (EGDMA) and practice. Nevertheless, roxithromycin residues accumulated
2’2-azobisisobutyronitrile (AIBN) as functional monomer, along the food chain may be potentially hazardous for
cross-linker and initiator, respectively. The scanning environment and human health[3]. In recent years, concerns
electron microscopy exhibited that the imprinted have been raised regarding the public health impact of the
occurrence of antibiotics in the aquatic environment[4].
polymers synthesized were uniform spheres with the
Besides, there are indication