文档介绍：SICENCE 新闻发布作者:张腾稿号: NRR-D-14-00177 依达拉奉促进机械性周围神经损伤后神经功能恢复的有效证明依达拉奉可以减轻缺血再灌注诱导的周围神经损伤, 但对机械性因素引起的周围神经损伤的治疗效果及机制不甚明了。来自中国大连医科大学附属第二医院南丰博士所领导的团队, 以止血钳钝性钳夹大鼠坐骨神经建立周围神经损伤模型, 连续 2 周腹腔注射 3mg/kg 依达拉奉干预。结果显示依达拉奉干预使周围神经损伤模型大鼠坐骨神经功能指数明显升高, 且坐骨神经中丙二醛含量下降, 超氧化物歧化酶活性上升, 同时 L 4-6 节段脊髓前角细胞中抗凋亡蛋白 Bcl-2 的表达上升, 促凋亡蛋白 Bax 的表达下降。表明依达拉奉可通过缓解自由基的损伤和抑制脂质过氧化,调节凋亡相关蛋白的表达,促进由于机械性因素损伤神经的再生。相关文献发表于《中国神经再生研究( 英文版)》杂志 2014 年9 月第 18 期。免疫组化染色显示,连续 2周腹腔注射 3mg/kg 依达拉奉治疗周围神经损伤模型大鼠后,脊髓前角细胞中 Bax 的表达减少 Article: " Edaravone promotes functional recovery after mechanical peripheral nerve injury ," by Teng Zhang, Zhengwei Li, Jianli Dong, Feng Nan, Tao Li, Qing Yu ( Department of Orthopedics, the Second Affliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China ) Zhang T, Li ZW, Dong JL, Nan F, Li T, Yu Q. Edaravone promotes functional recovery after mechanical peripheral nerve injury. Neural Regen Res. 2014;9(18):1709-1715. 欲获更多资讯: Neural Regen Res Edaravone promotes functional recovery after mechanical peripheral nerve injury Edaravone has been shown to reduce ischemia/reperfusion-induced peripheral nerve injury. However, the therapeutic effect of edaravone on peripheral nerve injury caused by mechanical factors is unknown. Researchers from the Second Affliated Hospital of Dalian Medical University, China led by Feng Nan established a peripheral nerve injury model by crushing the sciatic nerve