文档介绍：超声检查兔腹主动脉IMT及硬化指数动脉应力在诊断动脉粥样硬化中的价值宋树良 1宋庆达 2韩承河 3张家军 3夏利平 3,东野圣伊 3,盖永浩 3 200120 -中层厚度(intima-media thickness,IMT)及其功能变化探讨IMT及其功能改变诊断早期动脉硬化的价值方法新西兰大白兔30只随机分为正常饲料组CG12只高脂饲料组(OG) 18只分别于第0周4周8周10周和12周超声检查腹主动脉测量IMT于第4周末第8周末和第12周末计算其硬化指数stiffness index, SI和动脉应力(arterial strain, AS)变化比较CG和OG兔腹主动脉上述各指标的差异并于第4周末第8周末和第12周末完成超声检查测量后随机选择38只兔子放血处死取检查段腹主动脉进行大体检查和光镜病理学检查记录血管壁的结构变化和动脉粥样硬化形成的情况结果从第4周起OG兔出现高脂血症第8周以后动脉粥样硬化模型建立自第4周以后OG兔腹主动脉IMT与第0周获得的数据以及同一匹配时间的CG兔腹主动脉内膜- SI和AS中第8周以后CG和OG的SI和AS具有显著性差异P 并且与IMT 高度相关(P=) CG SI与观察时间无明显相关r== AS与观察时间呈负相关r= , P= 结论根据实验动物兔腹主动脉IMT改变并结合功能变化可以对实验动物兔动脉硬化做出诊断关键词动脉粥样硬化血管内膜-中层厚度血管功能超声显像 Ultrasonic Diagnosis of Arteriosclerosis by Evaluating the IMT, SI and AS of Abdominal Aorta in Model Rabbits: An Experiment Study Song Shuliang*, Song Qingda, Han Chenghe, et al. *Department of Ultrasound, Dongfang Hospital, Shanghai, 200120, China Abstract: ObjectiveTo assess the value of evaluatingarteriosclerosis by intima-media thickness (IMT) and stiffness index (SI) arterial strain (AS) on ultrasound in modelsrabbit. Methods Thirty male New Zealand White rabbits were divided randomly into normal control group (CG) and observation group (OG). Twelve rabbits in CG were fed mon food and 18 rabbits in OG were fed with fat-rich food. At the beginning and the end o