文档介绍：第13卷第8期 2011年8月辽宁中医药大学学报 U魄ONING UNIVERSITY OFTCM Aug.,2011 和胃颗粒干预功能性消化不良实验研究申珊珊。梁茂新。张宏(辽宁中医药大学方剂学科,辽宁沈阳110032) 摘要:目的:观察和胃颗粒对实验性功能性消化不良胃肠运动障碍的调节作用。方法:以正常小鼠、FD模型大鼠、家兔离体肠管为实验对象,气滞胃痛颗粒和多潘立酮片为阳性对照药物,观察和胃颗粒低、中、高剂量对胃肠运动的影响。结果:和胃颗粒能促进正常小鼠的肠推进,对FD模型大鼠的胃排空和肠推进亦有明显的促进作用,对家兔离体肠管的自主收缩具有抑制作用,并对乙酰胆碱作用下的离体肠管痉挛有抑制作用。结论:和胃颗粒对功能性消化不良有确切的调节作用,其干预效应可能与整体性调节胃肠功能紊乱有关。关键词:和胃颗粒;功能性消化不良;肠推进运动;胃排空;离体十二指肠中图分类号:R一322 文献标识码:A 文章编号:1673—842X(201 1)08—0193—03 Hewei Granule Experimental Intervention Functional Dyspepsia ofExperimental Research SHEN Shan-shan,LIANG Mao—xin,ZHANG Hong (Liaoning University ofTraditional Chinese Medicine,Shenyang 10032,Liaoning,China) Abstract:Objective:To observe Hewei Granule on experimental funotional dyspepsia regulation of gastrointestinal :Normal mice,FD rats,rabbits as experimental subjects invitro intestinal,Qizhiweitong particles and dompcridone as the positive control,observation Hewei Granule low, medium and high doses :The stomach and fried topromotenormal intestinal propulsion inmice。rats on the FD gastric emptying and intestinal propulsion alsosignificantly promote,on isolated rabbit intestine spontaneous contraction,and acetylcholine Under the inhibition ofin vitro :Hewei Granule on functional dyspepsia have the exact regulatory role,its effect