文档介绍:狂犬病病毒狂犬病rabies
Despite being 100% preventable, one person dies from rabies every ten minutes.
It is estimated that 55,000 people die worldwide from rabies each year.
-流行情况-
统计:
中国狂犬病发病数全球第2, 死亡率近100%
疫情最严重 5个省份分别是广西、贵州、四川、湖南和广东
-流行情况-
生物学性状
病毒形态: 似子弹状
是嗜神经病毒: 可在神经细胞中增殖, 并在胞浆中形成卵园形 嗜酸性包涵体(内基体Negri-body)
生物学性状
Electron micrograph of rabies virus in brain cells at 64,000x magnification. The bullets surrounding the smoothe gray circle are rabies.
The circle itself
is the negri body,
which can be seen
with a light microscope.
helical nucleocapsid (RNA plus
N protein)
G glycoprotein
SPIKES
lipid bilayer membrane
M protein
RHABDOVIRUSES
抵御力
56。C 30min灭活
100。C 2min全部死亡
常温 脑组织存活7~10d
1%甲醛、新洁而灭 灭活
易感动物
狼
猫
狗
蝙蝠
狐狸
狂犬病病毒
易感动物
致病性
传染源: 狂犬(主) 带病毒 动物
感染路径: 带病毒 动物 咬伤