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身份证出生日期:1973-11
不同比重罗哌卡因用于腰麻剖宫产的半数有效剂量
耿志宇 王东信
作者单位:100034 北京大学第一医院麻醉科
通讯作者:耿志宇,Email:gengzhiyu_******@,Tele;**********
【摘要】 目的 %重比重和轻比重罗哌卡因腰麻用于剖宫产的半数有效剂量(ED50),并比较其相对效价。 方法 腰硬联合麻醉下择期行剖宫产术的单胎足月初产妇40例,随机分为重比重罗哌卡因(H-R)组和轻比重罗哌卡因(L-R)组。局麻药的初始剂量为9mg,剂量间隔为1mg,按序贯法给药,每组各20例。有效病例的标准为20min内镇痛平面达到T7或以上,并且50min内硬膜外未追加任何药物即能完成手术。 结果 (95%CI:~),(95%CI:~),(95%CI:-)。 结论 (95%CI:~)(95%CI:~),二者接近等效。
【关键词】罗哌卡因;麻醉,脊柱;剖宫产术;剂量效应关系
The effect of baricity on the median effective dose(ED50) of intrathecal ropivacaine for cesarean section
GENG Zhi-yu, Wang Dong-xin. Department of Anesthesiology, First Hospital, Peking University, Beijing100034, China
Corresponding author: GENG Zhi-yu, Email:gengzhiyu_******@
【Abstract】Objective To determine the median effective dose (ED50) of intrathecal hyperbaric and hypobaric ropivacaine for elective cesarean section and to define their potency ratio using the up-and-down sequential allocation method. Methods We enrolled 40 parturients undergoing elective cesarean section with combined spinal-epidural anesthesia and randomized them to one of two groups to receive intrathecal % hyperbaric or hypobaric ropivacaine. The initial dose was 9mg, and the testing interval was set