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多奈哌齐联合红景天治疗阿尔茨海默病临床疗效评价
[【摘要】：^p ] 目的 观察多奈哌齐片联合红景天胶囊治疗阿尔茨海默病（Alzheimer disease，AD）的临床效果。 方法 68例确诊阿尔茨海默病患者，按随机原则分为观察组和对照组，对照组单用多奈哌齐治疗，观察组给予多奈哌齐联合红景天，疗程4周，治疗前后进行临床痴呆评定量表（CDR）、简易精神状态检查量表（MMSE）评分及生活自理能力（ADL）评分。 结果 观察组治疗后CDR、ADL评分均下降，MMSE评分升高，较对照组治疗差别有统计学意义。 结论 多奈哌齐抑制胆碱脂酶，减少神经细胞调亡，增强记忆；红景天抗氧自由基，改善脑部供血，二者联用对阿尔茨海默病疗效显着，宜推广临床应用。
[【关键词】：^p ] 多奈哌齐；红景天；阿尔茨海默病；临床痴呆评定量表；简易精神状态检查量表；生活自理能力评分
[中图分类号] [文献标识码] A [文章编号] 2095-0616（20________）07-59-03
Evaluation of clinical curative effect of donepezil bined with rhodiola rosea in treatment of alzheimer disease
PANG Wei1 ZHOU Chen2 CHEN Yan1
of Neurology， Zhanjiang Second People"s Hospital， Guangdong， Zhanjiang 524003， China； of Neurology， Zhanjiang Central People"s Hospital， Guangdong， Zhanjiang 524037， China
[Abstract] Objective To observe clinical curative effect of donepezil bined with Rhodiola Rosea capsule in treatment of Alzheimer disease （Alzheimer disease， AD）.Methods 68 patients who were diagnosed as Alzheimer disease were randomly divided into the observation group and the control control group was given donepezil for treatment while the observation group was given donepezil bined with Rhodiola course of disease was 4 of Clinical Dementia rating scale （CDR）， minimum mean-square error （MMSE） and activities of daily living （ADL） bef