文档介绍：Diseases of the Gastrointestinal Tract
消化系统疾病
The digestive system
The gastrointestinal tract
The liver and the biliary tract
The pancreas
Diseases of the GI Tract
Esophagus
Stomach
Small and
large intestines
Appendix
Barrett esophagus
Peptic ulcer
IBD
Anatomic/Development/motor Disorders
Inflammatory Diseases
Esophagitis
Gastritis
Enterocolitis
Appendicitis
Tumors
Adenoma
Reflux ~
Chronic ~
Carciod (NETs)
Normal anatomy and histology of the esophagus
Normal anatomy and histology of the esophagus
Length
Mucosa
Submucosa: glands
Muscularise propria
Adventitia
G-E junction
≠ S-C junction
Esophagogastric junction ≠
Squamous-Columnar junction
Esophagitis
Inflammation of the esophageal mucosa
Caused by a variety of agents
Physical
Chemical
Biologic
Reflux of gastric contents is the most important cause of esophagitis (reflux esophagitis)
Reflux esophagitis (返流性食管炎)
Elongation of the lamina propria papillae
Extending into the top third of the epithelium
Basal cell hyperplasia
>1/5 of the epithelial thickness
Intraepithelial inflammatory cells
Eosinophils, neutrophils and lymphocytes
Reflux esophagitis Clinical features
Age
Over 40y
Occasionally seen in infants and children
The dominant manifestation
Heartburn (烧心)
Regurgitation of a sour brash (返酸)
The potential consequences
Bleeding, ulceration, stricture
A tendency to develop Barrett esophagus