文档介绍：Allogeneic haematopoietic cell transplantation for multiple myeloma ? The allogeneic transplant has the advantage over the autologous transplant ? The graft does not contain tumor cells and the potential for a graft versus myeloma ( GvM ) effect Bone marrow transplantation in three patients with multiple myeloma Gahrton G , Ringd én O , L? nnqvist B , Lindquist R , Ljungman P. Acta Med Scand 1986;219(5):523-7. 瑞典卡罗林斯卡医学院 1983 Myeloablative conditioning ? Three patients with multiple myeloma received bone marrow grafts from HLA-identical sibling donors ? One of the patients, with IgA kappa myeloma , refractory to alkeran -prednisone therapy, is well and still without sign of disease 26 months post transplantation ? A second patient with Bence -Jones kappa myeloma is well, and skeletal pain and Bence - Jones proteinuria has disappeared 2 months after transplantation. ? A third patient with IgG -lambda myeloma died of effusive pericarditis shortly after transplantation. Acta Med Scand 1986;219(5):523-7 Conclusion ? Bone marrow transplantation may be indicated in a selective group of patients with multiple myeloma Acta Med Scand 1986;219(5):523-7 ? Out of 690 ic matched sibling donor transplants for MM ? 344 were performed during the period 1983- 93(all with BM ) [group 1] ? 356 during 1994-98 (223 with BM group 2 and 133 with PB group 3) ? the median age at transplantation of patients in group 1 was 43 years (range 21-62) ? In group 2 ,44 years (range 18_57) and in group 3, 46 years (range 25_60) ? TBI+CY tended to be monly used in group 1(37%) and 2 (39%) than in group 3 (27%) ? Melphalan containing regimes tended to be morely used in group 3 ? Melphalan or Busulphan + CY rarely ? Conditiong regime