奥沙利铂抗肿瘤及其耐药机制的研究进展.pdf

文档介绍：·专家讲座·
奥沙利铂抗肿瘤及其耐药机制的研究进展
任俊 柯重伟 *
（复旦大学附属上海市第五人民医院普外科，上海 200240）
摘 要 奥沙利铂是已被证明对结直肠肿瘤切实有效的铂类药物，并已成为该肿瘤的一线化疗方案用药，不仅如此，
奥沙利铂也应用于胰腺癌及胃癌的辅助治疗。然而，此类肿瘤患者常出现治疗失败，主要是由于这类患者存在先天性或
获得性耐药。因此，了解奥沙利铂的耐药机制对于克服这一现象并提高精准治疗水平非常重要。全文复习目前对于奥沙
利铂肿瘤耐药机制的最新研究进展，包括药物摄入、转出、DNA 损伤修复、细胞死亡、自噬在调控奥沙利铂耐药中的
关键作用。
关键词 肿瘤 ；奥沙利铂；耐药；细胞死亡；自噬
图分类号 ： 文献标志码 ：A 文章编号 ：1006-1533（2021）04-0003-06
Research progress in tumor-related resistance mechanisms of oxaliplatin
REN Jun, KE Chongwei
(Department of General Surgery of the Fifth People’s Hospital affiliated to Fudan University, Shanghai 200240, China)
ABSTRACT Oxaliplatin is a platinum drug that has been proven to be effective against colorectal tumors, and has become
the first-line chemotherapy regimen in treatment of this tumor. Not only that, oxaliplatin is also used in the adjuvant treatment of
pancreatic cancer and gastric cancer. However, treatment failure often occurs in patients with such tumors, which is mainly due
to congenital or acquired drug resistance. Therefore, understanding the resistance mechanism of oxaliplatin is very