文档介绍：摘要现代创伤敷料的一个重要研究方向就是将抗菌药物与创面保护材料复合,壳聚糖无纺布柔软舒适,不仅具有良好的保护创面特性,而且还具有止血、促进创面愈合等优良性能,其在创伤护理中应用日益广泛。近年来,环糊精改性纤维的研究较多,尤其是改性纤维素纤维的研究。改性后的纤维不仅保留了纤维本身的优良性质,同时也兼具了环糊精的包合性质。为了将抗菌药物更好地固着在壳聚糖纤维上,本文采用环氧***丙烷做交联剂,通过不同的工艺尝试将环糊精接枝到壳聚糖纤维上,通过傅里叶红外光谱、紫外分光光度计等检测手段对环糊精接枝壳聚糖纤维进行性能表征和分析,结果表明当以环氧***丙烷做交联剂时,环糊精能成功接枝到壳聚糖纤维上,如果以苯甲醛先保护壳聚糖时,其可顺利保护壳聚糖的氨基,但是环糊精不能接枝到经过苯甲醛预处理的壳聚糖纤维上。制备环糊精接枝壳聚糖纤维的工艺条件对接枝量影响显著,以反应时间、温度、环氧***丙烷添加量为主要影响因素,分析了这些因素对接枝量的影响。获得了环糊精接枝壳聚糖纤维的最优工艺条件为:环氧*** ml,反应温度25℃,后期反应时间48h, h。以左氧***沙星为模型药物,将接枝环糊精的壳聚糖纤维对其进行包合,并测试了在最优工艺下左氧***;在35℃时的释放量为 {妇;采用振荡法对其进行抗菌性能测试,结果表明改性的功能纤维具有明显的抗菌效果。关键词:环糊精,壳聚糖纤维,环氧***丙烷,接枝 bining硼伯microbial dmgs with wound dressmg would be an i111pon粕t d计ection旬rmodem dressing matcrials任om chitos锄fibers ha、,emorc excellent properties,both and good佗atures withpmtect访g wound、stopp访g bIeedillg andpromoting、Ⅳound healing and they are bcillg applied traum care recent yc盯s,more锄d more people甜e nerested cyclode)(trill伊afted血nctional砧ers due bmed properties of fibersand cyclode斌rin. LeonoXaciIl was chosen瓠a model drug of antimicrobial levonoxaciIl omo chitos锄助ers,di脑rent proces∞s ofmal【mg cyclodeXtrill矿aft on 舶crsby epichlorohydrill船crosS-linking agent had bcen tried thisp印既Four衙 trans南mi11劬red spectroscopy(FTIR),uhraVio^et Spectrophotomet巧were u∞d to veri匆and anaIyze thes咖ctWe锄d rel%smg results showed cyclode)(triIl could be graRed onto chitos锄 6bers. However, cyclode】(ITill could not beused t0modi匆fibe船wh朗benzaldehyde w硒uSed to protect锄iflo-孕-oup conditions mfluencillg g阻ftiIlg re鲫hs iIlcludedresponse tiIlle,temperature柚d ss p蹦mlcters '25℃temperature, h prc-reaction ∞,thc访clusion锄drel%s吨锄ounts of lcVonoxacill were and :Fulrtller property testshowed thefilnctioml丘bcr hadsatisfied觚tibacterical e虢ct,eSpec