文档介绍：Comprehensive Medicinal Chemistry II
Volume 8 : Case Histories
Elsevier, 2006
Editors-in-Chief: John B. Taylor and David J. Triggle
ISBN: 0-08-044513-6 (set)
Personal Essays
Introduction, Pages 1-5, . Comer
Reflections on Medicinal Chemistry Since the 1950s, Pages 7-15, H. Timmerman
Medicinal Chemistry as a Scientific Discipline in Industry and Academia:
Personal Reflections, Pages 17-27, . Ganellin
Some Aspects of Medicinal Chemistry at the Schering-Plough Research
Institute, Pages 29-51, . Ganguly
Case Histories
Viread, Pages 53-58, R. Oliyai and M. Fardis
Hepsera, Pages 59-63, R. Oliyai and M. Fardis
Ezetimibe, Pages 65-82, . Clader
Tamoxifen, Pages 83-102, . Jordan
Raloxifene, Pages 103-121, J. Lewis-Wambi and . Jordan
Duloxetine, Pages 123-135, . Thor and I. Yalçin
Carvedilol, Pages 137-147, . Ruffolo and . Feuerstein
Modafinil, A Unique Wake-Promoting Drug: A Serendipitous Discovery in Search
of a Mechanism of Action, Pages 149-156, F. Rambert, . Hermant and D.
Schweizer
Zyvox, Pages 157-171, . Brickner
Copaxone, Pages 173-185, D. Teitelbaum, R. Arnon and M. Sela
Ritonavir and Lopinavir/Ritonavir, Pages 187-197, . Kempf
Fosamax, Pages 199-212, . Reszka and . Rodan
Omeprazole, Pages 213-225, P. Lindberg
Calcium Channel α2–δ Ligands: Gabapentin and Pregabalin, Pages 227-246, .
Thorpe and . Taylor
Introduction
W er, TorreyPines Therapeutics, Inc., La Jolla, CA, USA
& 2007 Elsevier Ltd. All Rights Reserved.
Introduction 1
Case 1 1
Case 2 1
Case 3 3
Case 4 3
References 4
Introduction
The role of a medicinal chemist in drug discovery is the design, synthesis, and registration of the pound for
treating a particular disease condition