文档介绍：山西医科大学学报，2021 年 8 月，第 52 卷 第 8 期 ·989·
促红细胞生成Department of Cardio-
logy，Xi’an No 1 Hospital；*Corresponding author，E-mail：zengguangwei1026＠ 163. com）
Abstract： Objective To investigate the effect of helix B surface peptide（HBSP）on doxorubicin（DOX）-induced cardiotoxicity and
its regulation effect on autophagy. Methods Thirty-six C57BL ／ 6 mice were randomly divided into three groups（n ＝ 12）：control
group，DOX group and HBSP treatment group（DOX + HBSP）. The mice were intraperitoneally injected with DOX（15 mg ／ kg）in DOX
group and DOX + HBSP group. In addition，the mice in DOX + HBSP group were intraperitoneally injected with HBSP 30 μg ／ （kg·d）
for 7 d from the day of injection. Cardiac structure and function were observed，and the serum cTnT content，and the expression levels
of Caspase-3，cytochrome C，cleaved Caspase-3，Caspase-9，LC3B，Beclin1，LAMP2 and P62 were detected. Results Compared
with control group，the values of + dP ／ dt and - dP ／ dt were significantly decreased in DOX group（P ＜ 0. 01），the serum cTnT content
was increased （P ＜ 0. 01），some myocardial fibers were broken，disordered and vacuolated，the expression levels of Caspase-3，
cytochrome C，cleaved Caspase-3 and Caspase-9 were significantly increased（P ＜ 0. 01），and the ratio of LC3BⅡ ／